Asunto(s)
Anillo Fibroso/metabolismo , Materiales Biocompatibles Revestidos/síntesis química , Poliuretanos/síntesis química , Adhesivos Tisulares/síntesis química , Animales , Línea Celular , Supervivencia Celular/efectos de los fármacos , Materiales Biocompatibles Revestidos/administración & dosificación , Materiales Biocompatibles Revestidos/metabolismo , Colágeno/química , Haplorrinos , Inyecciones , Cinética , Fenómenos Mecánicos , Ratones , Cemento de Policarboxilato/química , Poliuretanos/administración & dosificación , Poliuretanos/metabolismo , Propiedades de Superficie , Temperatura , Termodinámica , Adherencias Tisulares/metabolismo , Adhesivos Tisulares/administración & dosificación , Adhesivos Tisulares/metabolismo , ViscosidadRESUMEN
Engineered skin coverings have been adopted clinically to support extensive and deep wounds that result in fewer healthy skin remaining and therefore take longer to heal. Nonetheless, these biomaterials demand intensive labor and an expensive final cost. In comparison to conventional bandages, which do not meet all the requirements of wound care, electrospun fiber mats could potentially provide an excellent environment for healing. In this work, we developed two nanostructured scaffolds based on polyamide-6 (PA-6) to be tested as a wound covering in a rat model of full-thickness incisional wound healing. The central idea was to create a bioconstruct that is simple to implement and biologically safe, with a high survival rate, which provides physical support and biological recognition for new functional tissues. An unmodified PA-6 and a soybean-modified PA-6 were employed as nanofibrillar matrices in this study. The biomaterials showed a dimensional homology to natural extracellular matrix components and neither in vitro toxicity nor in vivo side effects. Both polymeric scaffolds were resistant to the sterilization process and could promote the attachment of 3T3 fibroblast cells, besides successfully incorporating the growth factor PDGF-BB, which had its bioactivity extended for up to 12â¯h under simulated conditions. The modification of PA-6 chains with a fatty acid derivative increased the scaffold's surface free energy, favoring cell proliferation, collagen formation, and ECM secretion. These results confirm the potential of these materials as a topical dermal covering for skin regeneration.
Asunto(s)
Caprolactama/análogos & derivados , Glycine max/química , Polímeros/farmacología , Piel/patología , Cicatrización de Heridas/efectos de los fármacos , Células 3T3 , Animales , Becaplermina/farmacología , Caprolactama/farmacología , Adhesión Celular/efectos de los fármacos , Microambiente Celular/efectos de los fármacos , Chlorocebus aethiops , Masculino , Membranas Artificiales , Ratones , Nanopartículas/química , Nanopartículas/ultraestructura , Ratas Wistar , Piel/efectos de los fármacos , Factores de Tiempo , Células VeroRESUMEN
The Brazilian male beauty market occupies the second place in world consumption of cosmetics. Among the numerous products consumed by such audience is the capillary fixation mask, which is mainly composed by fixatives. These additives act on stabilizing the cosmetic emulsion, protecting the hair against moisture and also increasing the intensity of hair fixation. In this work, three formulations for modelling creams were prepared by different concentrations of the fixatives StylezeTM W20 and PVP K90 and their properties characterized by physicochemical, rheological and sensory analysis. The capillary masks produced were stable oil-in-water (O/W) emulsions with uniform droplets of 2.05-2.82 µm sizes and pseudoplastic thixotropic behavior (0.19 < n < 0.26). It was possible to correlate the increased concentration of PVP K90 to a greater thixotropy and an improved yarn fixation, despite the worsening in the spreadability of the formulations. These results suggest properly conducted rheological measurements can contribute to the prediction of the emulsion's sensory properties, which can save time and funds on the development of new cosmetics
